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姓名:曹林英职称:副教授 电话:15210260427
E-mail: caolinying226@hunau.edu.cn
个人简介
曹林英,女,博士,副教授,博士/硕士生导师,主要研究方向为新污染物健康效应与毒理机制。2018年进入湖南农业大学资源环境学院工作(神农学者青年英才I类人才引进),获得本校首个国家“博新计划”资助(2020年度),指导研究生/本科生获得国家奖学金及学科竞赛等多项奖励。近5年,主持国家级/省部级项目4项,参与国家级、省部级科研课题4项。共发表SCI论文三十余篇,以第一作者或通讯作者在环境领域权威顶刊EHP、EST等发表十余篇代表性论文,获授权发明专利3项。
工作经历
2023.01-至今 湖南农业大学环境与生态学院 副教授/博士生导师
2018.12-2023.01 湖南农业大学资源环境学院 副教授/硕士生导师
2020.06-至今 湖南农业大学 “博新计划”博士后(合作导师 印遇龙院士)
教育经历
2014.09—2018.06 中科院生态环境研究中心 环境科学 博士
2011.09—2014.06 中科院兰州化学物理研究所 分析化学 硕士
2007.09—2011.06 中南大学 制药工程 学士
学术兼职
Environmental Pollution, Environmental International, Environmental Research, Toxicology, Toxicology letters等杂志审稿人。
教学情况
承担《污染生态与生态毒理》、《科技论文写作》、《环境科学与工程前沿进展》、《研究生论文写作指导》等课程的教学工作
科学研究
近5年主持及参与的科研项目
1、国家自然科学基金青年项目,21906050,基于雌激素膜受体GPER探究新烟碱农药对乳腺癌增殖转移的影响及分子机制,2020.01-2022.12,26万,主持
2、国家“博新计划”,BX20200127,以小型猪为模型研究抗菌剂三氯卡班诱导脂代谢异常和肥胖的分子机制,2021.01-2022.12,63万,主持
3、中国博士后科学基金面上项目,2020M682567,雌激素相关受体在三氯生和三氯卡班干扰脂代谢中的调控作用及机制,2021.01-2022.12,8万,主持
4、湖南省自然科学基金青年项目,2020JJ5222,新烟碱农药通过雌激素膜受体GPER介导的雌激素干扰分子机制研究,2020.01-2022.12,5万,主持
5、湖南农业大学人才引进项目,2018.12-2023.12,50万,主持
6、湖南农业大学青年基金项目,19QN33,灭螺剂氯硝柳胺的雌激素干扰效应研究,2020.01-2021.12,1万,主持
7、湖南省重点研发项目,2019SK2281,入河水体重金属污染阻控与锑微污染深度净化关键技术,2019.07-2021.06,参与
8、国家自然科学基金面上项目,21777187,基于脂肪酸膜受体GPR40信号通路探讨全氟烷基化合物的胰岛素分泌功能干扰效应及其分子作用机制,2018.01-2021.12,65万,参与
9、国家自然科学基金面上项目,21876184,氯酚光催化降解毒性中间产物生成阻断动态研究及其机制探讨,2019.01-2022.12,65万,参与
10、中国科学院前沿科学重点研究项目,QYZDJ-SSW-DQC020, PBDEs对斑马鱼的生殖发育毒性及其机制,2016.08-2020.12,参与
近5年参加学术会议
1. 曹林英,第十一届环境化学大会. 哈尔滨,2022.(口头报告)
2. 曹林英,第七届生态毒理学大会. 桂林,2021(口头报告)
3. 曹林英,2020年环境与健康学术会议. 南宁,2020.(口头报告)
4. 曹林英. 第十届环境化学大会. 天津,2019.(口头报告)
5. 曹林英,任肖敏,郭良宏. 第九届环境化学大会. 杭州,2017.(口头报告)
6. Cao LY, Ren XM., Guo LH., BCEIA. Beijing, 2017.(展报)
7. 曹林英,任肖敏,郭良宏.中国化学会第30届学术年会.大连,2016.(展报)
8. Cao LY, Ren XM., Guo LH., BCEIA. Beijing, 2015.(展报)
9. 曹林英,任肖敏,郭良宏. 第八届环境化学大会. 广州,2015. (展报)
获奖及专利
1、获得2020年度国家“博新计划”资助
2、指导研究生获得研究生国家奖学金、湖南省优秀毕业生等
3、获得第五届全国大学生生命科学创新创业大赛指导教师一等奖
4、《荧光探针化合物及其制备方法和应用》,ZL202110820976.3,2021年,排名第一
5、《一种荧光标记的全氟烷基酸探针及其应用》,ZL201610543421.8,2018年,排名第二
6、《一种检测待测样品与GPR40结合能力的方法及其专用特异荧光探针》,201610121989.0,2016年,排名第二
主要论文
1. Cao Lin-Ying, Ren Xiao-Min*, Yang Yu, Wan Bin, Guo Liang-Hong*, Chen De, Fan Yong, Hydroxylated polybrominated biphenyl ethers exert estrogenic effects via nongenomic G protein-coupled estrogen receptor mediated pathways, Environmental Health Perspectives, 2018, 126 (5): 057005-1– 057005-13. (IF 11.035,中科院一区)
2. Sen He, Han Xiao, Cao Lin-Ying* et al, Benzotriazole ultraviolet stabilizers promote breast cancer cell proliferation via activating estrogen-related receptors α and γ at human-relevant levels, Environmental Science & Technology, 2022, 56: 2466−2475 (IF 11.357, 中科院一区)
3. Cao Lin-Ying, Zheng Zi-Ye., Ren Xiao-Min, Andersson Patrik L., Guo Liang-Hong, Structure-dependent activity of polybrominated diphenyl ethers and their hydroxylated metabolites on estrogen related receptor γ: in vitro and in silico study, Environmental Science & Technology, 2018, 52 (15): 8894–8902. (IF 11.357, 中科院一区)
4. Cao Lin-Ying, Ren Xiao-Min, Li Chuan-Hai, Zhang Jing, Qin Wei-Ping, Yang Yu, Wan Bin, Guo Liang-Hong, Bisphenol AF and bisphenol B exert higher estrogenic effects than bisphenol A via G proteincoupled estrogen receptor pathway, Environmental Science & Technology, 2017, 51 (19): 11423-11430. (IF 11.357, 中科院一区)
5. Xin Li, Sen He, Han Xiao, Ting-Ting He, Jia-Da Zhang, Zi-Rui Luo, Jie-Zhi Ma, Yu-Long Yin, Lin Luo*, Lin-Ying Cao*, Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies, Environment International, 2022, 170:107568 (IF 13.352, 中科院一区)
6. Xin Li, Jia-Da Zhang, Han Xiao, Sen He, Ting-Ting He, Xiao-Min Ren, Bing-Hua Yan, Lin Luo, Yu-Long Yin, Lin-Ying Cao*, Triclocarban and triclosan exacerbate high-fat diet-induced hepatic lipid accumulation at environmental related levels: The potential roles of estrogen-related receptors pathways. Sci Total Environ. 2023:160079. (IF 10.753, 中科院一区)
7. Lin-Ying Cao*, Yun-Hao Xu, Sen He, et al, Antimicrobial triclocarban exhibits higher agonistic activity on estrogen-related receptor γ than triclosan at human exposure levels: a novel estrogenic disruption mechanism, Environmental Science & Technology Letters, 2020, 7, 434−439. (IF 11.558,中科院一区)
8. Cao Lin-Ying, Ren Xiao-Min, Li Chuan-Hai, Guo Liang-Hong, Organophosphate esters bind to and inhibit estrogen-related receptor γ in cells, Environmental Science & Technology Letters, 2018, 5(2): 68-73. (IF 11.558,中科院一区)
9. Cao Lin-Ying, Ren Xiao-Min, Guo Liang-Hong, Estrogen-related receptor g is a novel target for Lower-Chlorinated Polychlorinated Biphenyls and their hydroxylated and sulfated metabolites, Environmental Pollution, 2019, 254 (11):113088-113096 (IF 9.988, JCR一区)
10. Sen He, Xin Li,Cao Lin-Ying* et al, The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors, Toxicology, 2021, 457, 152805. (IF 4.571, JCR一区)
11. Cao Lin-Ying, Wu Qin-Feng, Li Qiang, Shao Shi-Jun, Guo Yong, Visualizing the changes in the cellular redox environment using a novel profluorescent rhodamine nitroxide probe, New Journal of Chemistry, 2013, 37 (10):2991-2994. (IF 3.925,JCR二区)
12. Cao Lin-Ying, Yu Hui, Shao Shi-Jun, Wang Shuai, Guo Yong, Evaluating the antioxidant capacity of polyphenols with an off-on fluorescence probe and the mechanism study, Analytical Methods, 2014, 6 (18): 7149-7153. (IF 3.532,JCR一区)
13. Cao Lin-Ying, Wu Qin-Feng, Li Qiang, Shao Shi-Jun, Guo Yong, Fluorescence and HPLC detection of hydroxyl radical by a rhodamine-nitroxide probe and its application in cell imaging, Journal of Fluorescence, 2014, 24 (2): 313-318. (IF 2.525,JCR三区)
14 Qin Wei-Ping, Cao Lin-Ying, Li, Chuan-Hai, et al. Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40, Environmental Science & Technology, 2020,54 (6): 3428-3436. (IF 11.357,中科院一区)
15. Xiao-Min Ren, Lin-Ying Cao, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo*. Investigation of the binding interaction of fatty acids with human G protein-coupled receptor 40 using a site-specific fluorescence probe by flow cytometry, Biochemistry, 2016, 55: 1989-1996. (IF 3.321,JCR三区)
16. Xiao-Min Ren, Lin-Ying Cao, Yu Yang, Bin Wan, Su-Fang, Wang, Liang-Hong Guo*. In vitro assessment of thyroid hormone receptor activity of four organophosphate esters. J. Environ. Sci., 2016, 45: 185-190. (IF 6.796,JCR一区)
17. Hui, Yu, Lin-Ying, Cao, Fei-Fei, Li, Qin-Feng, Wu, Qiang, Li, Shuai, Wang, Yong, Guo*. The antioxidant mechanism of nitroxide TEMPO: scavenging with glutathionyl radicals. RSC Adv., 2015, 5: 63655-63661. (IF 4.036,JCR二区)
18. Xiao-Min Ren, Wei-Ping Qin, Lin-Ying Cao, Jing Zhang, Yu Yang, Bin Wan, Liang-Hong Guo. Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications. Toxicology, 2016, 366-367: 32-42. (IF 4.571, JCR一区)
19. Li Chuan-Hai, Ren Xiao-Min, Ruan Ting, Cao Lin-Ying, Xin Yan, Guo Liang-Hong, Jiang Gui-Bin, Chlorinated polyfluorinated ether sulfonates exhibit higher activity toward peroxisome proliferator activated receptors signaling pathways than perfluorooctane sulfonate, Environ. Sci. Technol., 2018, 52:3232-3239. (IF 11.558,中科院一区)
20. Sun Run-Xia, Sun Yue, Xie, Xian-De, Cao Lin-Ying et al. Bioaccumulation and human health risk assessment of DDT and its metabolites (DDTs) in yellowfin tuna (Thunnus albacares) and their prey from the South China Sea. Marine Pollution Bulletin, 2020, 158: 0-111396. (IF 7.001, JCR 一区)
著作教材
参编著作《畜禽粪便资源化利用新技术》、《矿山酸性废水治理》两部
研究生培养情况
已毕业硕士:何森
在读硕士:李鑫、何婷婷、张佳大、汤蕾、张世科
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