姓名：曹林英   职称：副教授   电话：15210260427

E-mail:caolinying226@hunau.edu.cn

个人简介

曹林英，女，博士，副教授，博士生导师，国家“博新计划”入选者（2020年度）。2018年于中科院生态环境研究中心获环境科学博士学位，同年以“神农学者青年英才Ⅰ层次”人才进入湖南农业大学工作，主要研究方向为新污染物健康效应与毒理机制、新污染物生物检测技术开发。主持国家级/省部级项目5项，参与国家级/省部级项目6项；共发表SCI论文30多篇，以第一作者/通讯作者在环境领域权威顶刊EHP、EST等发表十余篇代表作，获授权发明专利3项，参编专著2部；指导研究生/本科生获国家奖学金、校长奖学金、省优秀毕业生及学科竞赛等多项奖励。

工作经历

2023.01-至今  湖南农业大学环境与生态学院  副教授/博士生导师

2018.12-2023.01  湖南农业大学资源环境学院   副教授/硕士生导师

2020.06-2023.11  湖南农业大学  “博新计划”博士后（合作导师 印遇龙院士）

教育经历

2014.09—2018.06，中科院生态环境研究中心，环境科学，博士，导师：郭良宏

2011.09—2014.06，中科院兰州化学物理研究所，分析化学，硕士，导师：郭勇

2007.09—2011.06，中南大学，制药工程，学士

教学情况

承担《污染生态与生态毒理》、《科技论文写作》、《环境科学与工程前沿进展》、《研究生论文写作指导》、《可持续生态学》等课程的教学工作

科研项目

[1]    国家自然科学基金青年项目，21906050，基于雌激素膜受体GPER探究新烟碱农药对乳腺癌增殖转移的影响及分子机制，2020.01-2022.12，主持

[2]    国家“博新计划”，BX20200127，以小型猪为模型研究抗菌剂三氯卡班诱导脂代谢异常和肥胖的分子机制，2021.01-2022.12，主持

[3]    中国博士后科学基金面上项目，2020M682567，雌激素相关受体在三氯生和三氯卡班干扰脂代谢中的调控作用及机制，2021.01-2022.12，主持

[4]    湖南省自然科学基金面上项目，2024JJ5175，基于雌激素信号通路探究甲氧基丙烯酸酯类杀菌剂的乳腺癌诱导风险及分子机制，2024.01-2026.12，主持

[5]    湖南省自然科学基金青年项目，2020JJ5222，新烟碱农药通过雌激素膜受体GPER介导的雌激素干扰分子机制研究，2020.01-2022.12，主持

[6]    湖南省教育厅优青项目，22B0201，典型农用杀菌剂噁唑菌酮对映体的雌激素干扰效应及分子机制，2022.01-2024.12，主持

[7]    湖南省重点研发项目，2023NK2029，典型农区水土环境新污染物高效筛查技术研究与产品创制，2023.07-2025.07，课题负责人

[8]    湖南省重点研发项目，2024JK2159，大宗农产品安全风险溯源技术研究与管控平台建设及应用，2024.07-2026.07，课题负责人

[9]    湖南农业大学人才引进项目，2018.12-2023.12，主持

[10]              湖南农业大学青年基金项目，19QN33，灭螺剂氯硝柳胺的雌激素干扰效应研究，2020.01-2021.12，主持

[11]              国家自然科学基金面上项目，21777187，基于脂肪酸膜受体GPR40信号通路探讨全氟烷基化合物的胰岛素分泌功能干扰效应及其分子作用机制，2018.01-2021.12，参与

[12]              中国科学院前沿科学重点研究项目，QYZDJ-SSW-DQC020, PBDEs对斑马鱼的生殖发育毒性及其机制，2016.08-2020.12，参与。

获奖及专利

[1]    指导研究生获得国家奖学金、校长奖学金、湖南省优秀毕业生等

[2]    获得第五届全国大学生生命科学创新创业大赛指导教师一等奖

[3]    《面向农业绿色发展的国际视野人才培养创新与实践》，湖南农业大学教学成果二等奖，2025，排名第六

[4]    国家发明专利，《荧光探针化合物及其制备方法和应用》，ZL202110820976.3，排名第一，已授权

[5]    国家发明专利，《一种荧光标记的全氟烷基酸探针及其应用》，ZL201610543421.8，排名第二，已授权

[6]    国家发明专利。《一种检测待测样品与GPR40结合能力的方法及其专用特异荧光探针》，ZL201610121989.0，排名第二，已授权

发表论文

[1]    Cao Lin-Ying, Ren Xiao-Min, Yang Yu, Wan Bin, Guo Liang-Hong, Chen De, Fan Yong, Hydroxylated polybrominated biphenyl ethers exert estrogenic effects via nongenomic G protein-coupled estrogen receptor mediated pathways, Environmental Health Perspectives, 2018, 126 (5): 057005.

[2]    Lei Tang, Xin Li, Shi-Ye Zhu, Yu-Ke Wan, Shi-Ke Zhang, Jie-Zhi Ma, Yuan Yang, An-Wei Chen, Lin Luo,* and Lin-Ying Cao*, 6PPD and 6PPD quinone induce endometrial cell dysfunction via activating ERα and GPER at human-relevant levels, Environmental Science & Technology, 2025, 59: 9918-9929

[3]    Sen He, Han Xiao, Shuang Luo, Xin Li, Jia-Da Zhang, Xiao-Min Ren, Yuan Yang, Xian-De Xie, Yao-Yu Zhou, Yu-Long Yin, Lin Luo*,Cao Lin-Ying*, Benzotriazole ultraviolet stabilizers promote breast cancer cell proliferation via activating estrogen-related receptors α and γ at human-relevant levels, Environmental Science & Technology, 2022, 56 (4): 2466−2475

[4]    Cao Lin-Ying, Zheng Zi-Ye., Ren Xiao-Min, Andersson Patrik L., Guo Liang-Hong, Structure-dependent activity of polybrominated diphenyl ethers and their hydroxylated metabolites on estrogen related receptor γ: in vitro and in silico study, Environmental Science & Technology, 2018, 52 (15): 8894–8902.

[5]    Cao Lin-Ying, Ren Xiao-Min, Li Chuan-Hai, Zhang Jing, Qin Wei-Ping, Yang Yu, Wan Bin, Guo Liang-Hong, Bisphenol AF and bisphenol B exert higher estrogenic effects than bisphenol A via G protein coupled estrogen receptor pathway, Environmental Science & Technology, 2017, 51 (19): 11423-11430.

[6]    Xin Li, Sen He, Han Xiao, Ting-Ting He, Jia-Da Zhang, Zi-Rui Luo, Jie-Zhi Ma, Yu-Long Yin, Lin Luo*, Lin-Ying Cao*, Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies, Environment International, 2022, 170:107568

[7]    Xin Li, Jia-Da Zhang, Han Xiao, Sen He, Ting-Ting He, Xiao-Min Ren, Bing-Hua Yan, Lin Luo, Yu-Long Yin, Lin-Ying Cao*, Triclocarban and triclosan exacerbate high-fat diet-induced hepatic lipid accumulation at environmental related levels: The potential roles of estrogen-related receptors pathways. Science of the Total Environment. 2023, 858:160079.

[8]    Jia-Da Zhang, Sen He, Ting-Ting He, Chuan-Hai Li, Bing-Hua Yan, Yuan Yang, Jian Yang, Lin Luo, Yu-Long Yin, Lin-Ying Cao*, Triclocarban exhibits higher adipogenic activity than triclosan through peroxisome proliferator-activated receptors pathways. Environmental Pollution, 2024, 342:123030

[9]    Ting-Ting He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shiye Zhu, Jianhua Zeng, Lin Luo, Yu-Long Yin, Lin-Ying Cao* Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways. Science of the Total Environment. 2024, 931: 172782.

[10]              Lin-Ying Cao*, Yun-Hao Xu, Sen He, Xiao-Min Ren, Yuan Yang, Shuang Luo, Xian-De Xie, Lin Luo*, Antimicrobial triclocarban exhibits higher agonistic activity on estrogen-related receptor γ than triclosan at human exposure levels: a novel estrogenic disruption mechanism, Environmental Science & Technology Letters, 2020, 7(6), 434−439.

[11]              Cao Lin-Ying, Ren Xiao-Min, Li Chuan-Hai, Guo Liang-Hong, Organophosphate esters bind to and inhibit estrogen-related receptor γ in cells, Environmental Science & Technology Letters, 2018, 5(2): 68-73.

[12]              Cao Lin-Ying, Ren Xiao-Min, Guo Liang-Hong, Estrogen-related receptor g is a novel target for Lower-Chlorinated Polychlorinated Biphenyls and their hydroxylated and sulfated metabolites, Environmental Pollution, 2019, 254 (11):113088-113096

[13]              Shike Zhang#, Xinyi Su#, Jiada Zhang, Tingting He, Lei Tang, Zepei Zhao, Linying Cao∗, Tire rubber derivative 6PPD and 6PPD-Q induce lipid accumulation in hepatocytes through ERRγ pathway, Journal of Environmental Sciences, 2025, 156: 173-184.

[14]              Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo,* Lin-Ying Cao*, The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors, Toxicology, 2021, 457, 152805.

[15]              Cao Lin-Ying, Wu Qin-Feng, Li Qiang, Shao Shi-Jun, Guo Yong, Visualizing the changes in the cellular redox environment using a novel profluorescent rhodaminenitroxide probe, New Journal of Chemistry, 2013, 37 (10):2991-2994.

[16]              Cao Lin-Ying, Yu Hui, Shao Shi-Jun, Wang Shuai, Guo Yong, Evaluating the antioxidant capacity of polyphenols with an off-on fluorescence probe and the mechanism study, Analytical Methods, 2014, 6 (18): 7149-7153.

[17]              Cao Lin-Ying, Wu Qin-Feng, Li Qiang, Shao Shi-Jun, Guo Yong, Fluorescence and HPLC detection of hydroxyl radical by a rhodamine-nitroxide probe and its application in cell imaging, Journal of Fluorescence, 2014, 24 (2): 313-318.

[18]              Qin, Wei-Ping, Cao, Lin-Ying, Li, Chuan-Hai, et al. Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40, Environmental Science & Technology, 2020，54 (6): 3428-3436.

[19]              Xiao-Min Ren, Lin-Ying Cao, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo*. Investigation of the binding interaction of fatty acids with human G protein-coupled receptor 40 using a site-specific fluorescence probe by flow cytometry, Biochemistry, 2016, 55: 1989-1996.

[20]              Xiao-Min Ren, Lin-Ying Cao, Yu Yang, Bin Wan, Su-Fang, Wang, Liang-Hong Guo*. In vitro assessment of thyroid hormone receptor activity of four organophosphate esters. Journal of Environmental Sciences, 2016, 45: 185-190.

学术兼职

全国本科毕业论文（设计）抽检评审专家库专家、“长沙市科技评审(评估)专家库”专家、省自然科学基金评审专家，Environmental International、Journal of Hazardous Materials、Environmental Pollution、Science of the Total Environment、Environmental Research、Ecotoxicology and Environmental Safety、Journal of Environmental Sciences、Toxicology等期刊审稿人。

教材专著

参编著作《畜禽粪便资源化利用新技术》、《矿山酸性废水治理》两部

研究生培养情况

已毕业硕士：何森、李鑫、何婷婷、张佳大、汤蕾、张世科

在读博士/硕士：万聿可、赵泽培、胡颖煌、徐上钧、刘亿、詹俊珊

欢迎有环境、生物、化学、毒理学和公共卫生等背景的学生报考研究生！